How well are you processing your Folate with MTHFR

How well are you processing your Folate with MTHFR

MTHFR is an acronym for an enzyme that changes the folate that you eat into an active form that you can use in your body.

How it gets more confusing is that the MTHFR gene and the enzyme have a very similar name! 

Simply put, the MTHFR gene makes the MTHFR enzyme. 

In more scientific language the gene, MTHFR (aka 5,10-methylenetetrahydrofolate reductase) gene makes the protein, MTHFR (methylenetetrahydrofolate reductase) enzyme.

That’s a bit of a mouthful. So, it is MTHFR for short.

Simply, without this one major working efficiently you may not be able to Methylate properly.  Methylation is a big name for a simple transfer of one Carbon and 3 Hydrogen atoms that when donated and received starts a cascade of biochemical actions. 

This one gene has been highly researched and is very significant in many disorders and disease processes, including Thyroid function.  And we can see why when folate is needed for cell growth and repair and involved with DNA and RNA replication.

We all know that folate is imperative to start taking before and during pregnancy. This is because the folate is involved in making new cells and without it can cause Neural tube defects which are severe birth defects of the brain and spine of the newborn.

We can see in a diagram of a pathway that the folate takes to get from what is in your food, or supplements.  When you ingest it, it passes to the small intestine and is processed, almost like conveyor-like process and is altered by a number of enzymes. This process uses B2, B3, B6, B12, Vitamin C, Zinc and an acidic environment.

The basic outline looks like this:

Unfortunately, the synthetic form, Folic Acid, that is widely included in many processed foods and supplements block the natural folate from converting into the active, and much-needed form of 5-MTHF.

It is extremely common that the words folate and folic acid be used interchangeably without much thought as to their true meaning.

First of all Folate

  • Also called Vitamin B9
  • The natural form that you get from whole foods
  • Needed for DNA production and RNA repair
  • Needed for neurotransmitters and detoxification
  • Needed for formation of RBC, WBC and Platelets

Folic Acid

  • This is a synthetic form
  • Commonly used in supplements and added to foods – check bread and cereal labels
  • The enzyme that processes Folic acid works very slowly and can only process 150-200mcg per day
  • Folic Acid that is not processed is called Un-Metabolised Folic Acid (UMFA) which is of no value in the body

Then there is Folinic acid

  • This is supplement is also called 5-formyl tetrahydrofolate
  • Important for making DNA
  • In the body this is made using B6 and Magnesium
  • This still relies on being converted into the active folate form by MTHFR

And finally: 5-MTHF

  • Also known as Active Folate, 5-methyltetrahydrofolate, 5- methyl THF, or methylfolate
  • This is produced at the end of the Folate pathway by the enzyme MTHFR
  • An important doner for Methyl groups for the Methylation Cycle

When you get your genes tested for MTHFR the results show that you are a carrier of one or two of the genes, C677T or the A1298C.

To understand what your results mean, I need to take you back a step or two and talk about genes and the basics of how they express in the body.

To make a gene you need two parts.  One is inherited from each parent to make a pair. When both parents give their child matching genes it is called Homozygous (Homo = Same). When each parent gives their child a different gene that is called Heterozygous (Hetero = Different).

A gene is made up of a Helix shape with pairs of nucleotides.  These pairs carry genetic information to make proteins and can be very on long strands of DNA.

It has been discovered that there are common mistakes in gene sequencing and these are called polymorphisms. Poly = many, and morphisms = forms.

One mistake is called a single nucleotide polymorphism, snp for short.

When making the MTHFR gene there has been recognised as many as 34 snps. Two main ones have been researched extensively and they cause consequences within the body.

These are:

MTHFR C677T

  • Sits at position 677 along the chain
  • It means a nucleotide base called Cytosine (C) is swapped out for Thymine(T)
  • When this gene uses this base code to make the enzyme it will switch the protein that is used from alanine to valine.

MTHFR A1298C

  • Sits at position 1298 along the chain
  • This means that a nucleotide called Adenine (A) is swapped out for a Cytosine (C)
  • When this gene uses this base code to make the enzyme it will switch the protein that is used from glutamate to Alanine.

So, What are your chances of having an MTHFR polymorphism?

There was a study in 2003, published where 7,130 newborns from 16 areas in the Americas, Europe, Russia, China, and Australia (NSW) were tested. Newborn babies were tested,d 500 of them from New South Wales.  7.5% were found to have two copies of the gene with 41% of the population were found to have 1 copy of the Gene.

MTHFR Gene Results Classification

Your personal results will tell you if you have the gene polymorphism. 

MTHFR C677T Heterozygous (one snp) = 40% loss of function

MTHFR C677T Homozygous (two snps) =  70% loss of function

MTHFR A1298C Heterozygous (one snp) = 20% loss of function (research not known)

MTHFR A1298C Homozygous (two snps) = 40% loss of function

MTHFR C677T & MTHFR A1298C heterozygous = compound heterozygous = 50% loss of function

If I have you curious now, yes, you can absolutely just test for MTHFR.  Your GP may run a test, and as far as I know, it is not covered by Medicare.

You can do this via blood or saliva, let me know if you would like to be tested and I will arrange this for you.

However, before you do, you may want to consider having more than one gene tested, because like anything it is just one tiny piece to a larger puzzle. You could be tested and find that you are low risk, however, other snps in the pathways may be an issue, so therefore your coping mechanisms may be just a low as if you were to have a homozygous snp.

There are a few companies that offer genetic testing, both online or through your health professional.

Then what do you do about your snps, besides learning to live with them and not against them is key. The most important thing you can do easily and straight up is eating as clean as possible supplying the body with natural nutrients, and then diving into other environmental factors that may be inhibiting the function of your genes that are expressing snp symptoms.

What kind of body are you living in?  If it is a hypothyroid, one, you will be slow functioning and perhaps auto-Immune.  Both conditions are affected by each other moment by moment.

The thyroid is trying its very best to keep the body regulated when it is being besieged by antibodies and the antibodies and the inflammatory cascade is like a run-away train because the body doesn’t have the resources to calm it down.

Let’s bring in a major player in both of these instances, and that is the gut.  I’d like you to take a moment and think about what you ate yesterday and how you woke up feeling today?  Were you alert and ready to leap out of bed and nail your day, or were you sluggish, a little sore and feeling ‘off, or worse, you hardly slept are very sore and in pain, and have to really push yourself to face another day?

I’m going to make the assumption that there that you are not jumping out of bed feeling awesome, because you wouldn’t be looking for sources, like mine to help you feel better.

Or, the second scenario (you are sluggish, a little sore, and feeling ‘off’) is typical of sluggish metabolism and potential auto-immune brewing or early stages of it, and the final scenario (very sore and in pain and have to really push yourself to face another day) is where that inflammatory cascade is most likely creating physical change and damaging as we speak.

These things don’t just happen overnight.  They take years, even decades to develop.  Thyroid antibodies can take 7 years to develop and show up in blood tests. 

Back to my question earlier, what did you eat yesterday?  Unfortunately, this is where it gets really tricky, because while yesterday’s food may not trigger your symptoms, (but maybe the most obvious) it’s the day before, or even the week before may have as well, so it makes working out which foods are activating your immune system really difficult and challenging.  

Then, what starts to happen we can start to eliminate foods in a desperate bid find that offending food.  I know how difficult this is, because when I had my bad flares of Psoriatic Arthritis, I did the same. Have you ever done that? Taking out healthy foods from your diet, becoming even more reactive to foods that once you could eat? You think that you are getting healthier, but instead, you feel like you are getting sicker and sicker, and you most likely are, as you are eliminating major sources of vitamins and minerals, to keep your body working.

So, what’s going on, on the inside?

Basically, the digestive tract is a big long tube from beginning to end.  That tube lining is like the skin covering your body but it’s on the inside, but it has different linings in each area.  For example, the stomach’s cells can handle the strong hydrochloric acid, that your hands could not, the small intestines are almost porous-like and are dynamic, and flexible to the foods that are floating past.

When you think about it, those tissues are exposed to the outside world, so not only do they have their methods of selectively nutrients to enter the body, they also have to have some protection.

Like think of them as being rows of gates, and then there is a guard to make sure the gates are being opened and closed to the people having a guard at the gate is your immune system.

The gut has an army of immune cells just hanging around on the inside wall of the digestive system, just keep watch and making sure nothing untoward is coming in.

So, you may have heard of ‘leaky gut’, this term is used quite freely and it is really bad if you have it. Well, we all do to a certain extent, the cells need to pull apart sometimes just to let some larger particles come through, like curcumin.  But we want it to close again once we have accepted that larger particle.

Unfortunately, by eating the wrong foods for a long time, we can inadvertently have allowed the connections of the cells to become weak.  Then what happens is normal good food can escape into where the immune system is and be seen as baddies and we have an immune attack.

When this happens for long enough, we can trigger an auto-immune response in our body because normal tissue is mistaken for problems.  The most common food trigger is gluten for Hashimotos.

Rheumatoid and other autoimmune diseases can be flared or activated by the imbalance of the gut being constantly activated by food – and in many cases it can still be good food, which is really unfortunate because then we start missing out on essential nutrients we need to operate our body and that’s when our friend cortisol begins to take over and our body starts living in a stress response, our blood sugars become unbalanced, we are tired, feeling low, unmotivated, sore, and over time, become more anxious and susceptible to the hits of life.

The first thing is to begin putting healthy food into the system.  Of course, eliminate the trouble foods that you know aren’t working for you, but then work on the gut.  Because it is not the food, it is the environment.  Long-term restoration is key, if you have an auto-immune issue, while a probiotic will help, it’s not going to change your gut microbiome and calm down that inflammation to the extent that you need it to.

There are so many gut irregularities to go into, there are certainly some good gut support nutrients, but I have seen over and over, that eating a nutrition plan that is matched to your body through your own blood has amazing outcomes.  Then backing that up with supporting the gut helps regulate and calm the immune system at the front line so to speak.

If you’d like to know more about this or other topics, you are welcome to join my free membership on face book. Thyroid, Metabolic, Hormone Harmony Hub. 

I’d love to see you there

Inspiring Wellness

 

Beth  

 

References

[1]Benjamin Lynch ND, Folate Metabolism and MTHFR: Introductory Overview of an Essential Gene

https://www.genome.gov/genetics-glossary/Genetic-Code

https://www.sciencedirect.com/science/article/pii/S2213158212000174

https://www.ncbi.nlm.nih.gov/books/NBK6561/

Leclerc D, Sibani S, Rozen R. Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021155/

Nefic H, Mackic-Djurovic M, Eminovic I. The Frequency of the 677C>T and 1298A>C Polymorphisms in the Methylenetetrahydrofolate Reductase (MTHFR) Gene in the Population. Med Arch. 2018;72(3):164-169. doi:10.5455/medarh.2018.72.164-169

Stress & Mood, how your COMT & MAO affect you

Stress & Mood, how your COMT & MAO affect you

Previously I have spoken about the COMT enzyme and how it can play havoc with your hormone, oestrogen. 

This very same Gene and enzyme also break down your Dopamine and Adrenal hormones.

If you have inherited a ‘wonky gene’ and this enzyme is processing slowly, it will process your Dopamine and Adrenaline pathways slowly, this may lead to having symptoms of the particular neurotransmitters remaining longer in the system. 

Like anything, having too much of a good thing can be okay for a while but can soon swing the other way. You may be confident with energy, but then maybe workaholic, or have trouble with winding down and relaxing. 

Having too much of the activity of COMT enzyme will mean that the process works faster, clearing the adrenaline, noradrenaline and dopamine, then causing a lovely sense of calmness, being good-tempered, with no problems with sleep, and responding well to stress.  However, it may also show as having difficulty completing tasks, forgetfulness, low focus, lack of confidence.  There also are issues with peri and menopause due to low hormones as they are being cleared quickly.

There is another important gene and enzyme called MAO, MonoAmine Oxidase. 

This breaks down your Serotonin, which is your sleep hormone, Dopamine, reward hormone, and Adrenaline and Noradrenaline hormones.

If you have a fast MAO, it means that the enzyme is working faster, and it breaks down Serotonin quicker. Adequate Serotonin helps us feel happy, optimistic, and self-confident.  When we process this neuro-transmitter faster, we can have low self-esteem, little faith in ourselves, and can be depressed.

If you find yourself reaching for carbs to help you feel better, you may be self-medicating to lift your mood.  But what happens then of course on a physical level, is that you tend to abuse high sugar content foods and that comfort eating increases your insulin and sugar levels over time.

Serotonin then goes on to make Melatonin so if you have poor serotonin levels you will also have trouble with sleep.  Some people have a habit of having a snack before bed or even get up in the middle of the night to have something to eat because it helps them sleep.

Instead of replacing it with a Melatonin supplement, the best thing to do is to eat sensible amounts of protein during the day that will supply the necessary amino acids to make and stabilise your melatonin and serotonin.

Tryptophan is an essential protein nutrient for these to be made and when I say essential, it means that you have to eat it, to get it.  It is not something that the body can make.  So, you need to ensure you are eating good food sources of it like:

Chicken and Turkey, Beef, Pork, Tofu, Salmon, Soy Bean, Milk, Pumpkin Seeds, Oats, and Eggs are the highest-ranked sources.

The interesting thing is that you need niacin, (Vitamin B3) in the pathway for Glucose (sugar) metabolism and that if you are not getting your requirement of B3 through the diet, Tryptophan can also make B3 as a backup.

This MAO enzyme also is responsible for processing your Dopamine neurotransmitter, which gives you feelings of satisfaction, achievement, and feelings of euphoria after an adrenaline hit AND it is responsible for processing your Adrenaline and Noradrenaline which are used in your flight or fight situation and long-term stress along with COMT.

A slow MAO could see you having difficulties falling asleep, headaches, mood swings, have anxiety that lasts a while, and experience rage or be aggressive, and have trouble relaxing because you can’t get rid of the adrenaline and dopamine fast enough.

If you have a fast MAO then you may have some sort of addition, experience ADHD, have carb and sugar cravings, depression, fatigue, difficulty staying asleep, and feel flat because you are not keeping your dopamine and adrenaline

So, that’s a lot to take in, do you resonate with any of it?

The great thing is, these genes are able to be managed, and it comes down to balance and common sense. 

A good nutritional daily consumption of proteins and carbohydrates in the way of fresh and varied vegetables, and some fruits is ideal for balancing out these crazy enzymes as a great place to start.

If you’d like to know more, you are welcome to join my free membership on facebook. Thyroid, Metabolic, Hormone Harmony Hub. 

 

I’d love to see you there

 

Inspiring Wellness

 

Beth 

A Wonky What? COMT Gene & Oestrogen

A Wonky What? COMT Gene & Oestrogen

This gene can be quite the problem with both your adrenals and your most well-known female hormone, Oestrogen. 

Before I jump in, what is a gene?

A gene tells the body to make an enzyme which then directs a chemical reaction. If that’s a bit too much to think about, then in a more simplistic way, visualise one of those domino cascades that you see.  You start the push over with your finger (that’s the gene) then the dominos (the enzymes) and at the end the last domino it sends a ball rolling and that is like the chemical reaction.

I’m going to jump straight into the nitty gritty of this particular gene, because I hear it often expressing itself in the symptoms of my clients. 

If you have had horrible experiences with your periods, heavy periods, I mean, change your pad or tampon every 30 mins or wake to find you have slept in a blood bath and have to put your sheets on soak in the middle of the night.  Or when you go to the toilet, there are big clots left on your pad or fall into the bowl.  That kind of heavy.

And your belly feels as if it’s dragging on the ground and the pain is unbearable.  You just wanna lie on the couch with a hottie and cancel your day.  You may have even been told you have fibroids or endometriosis.

Also you have lumpy sore breasts, fluid retention and weight gain before your period and you’re also feel low and moody.

This can be a sign of Oestrogen dominance.  If you have read my blogs on Progesterone you will have learned that Progesterone and Oestrogen cohabitate in a balance, and if progesterone is low, particularly due to stress, then Oestrogen will naturally be high. 

This scenario has a similar outcome, but the cause is different. It is a Gene with an acronym named COMT.

This stands for Catechol-O-Methyltransferase. 

This big name breaks down the two different ways that this gene works.

One way works on Oestrogen and the other way is with your sense of achievement and Adrenals.  I’ve covered Adrenals in another blog.

Before I continue, I just need to take you back one step. 

Each one of our inherited genes is a pair.  One half from our Mum and the other from our Dad. 

Research is amazing and has discovered that there are common faults in our genes.  This fault is referred to a snp.  Single Nucleotide Polymorphism. I prefer to call it a ‘wonky gene’ for ease.  They usually slow or speed up the function of the enzyme that they code to make.

What is interesting is that the same wonkiness is the same for many people and not only that, some genes can be wonky without having any difference to the functioning of the body and yet there are some significant ones, of which COMT is one.

So, what does COMT do?  Well, for the heavy periods, fibroids and endometriosis, I mentioned before, that is a sign of a slow enzyme.  This means that Oestrogen is not able to break down very well and is being backed up or becomes ‘dominant’. 

Usually clinical symptoms will let us ‘hear’ this enzyme. Testing your genes also gives us the exact outcome of the snp, and you can also find this information from a DUTCH, (Dried Urine test for Comprehensive Hormones), which is an optional test to consider in my Hormone Harmony Method. In the DUTCH test we can learn how your Oestrogen is clearing, by assessing the metabolites, which is the broken-down parts of Oestrogen that is cleared by the body.

Not only do you then have an issue with the self-regulating of your natural Oestrogens, throw into the mix a little bit (quite a lot usually) of stress which will then lower your progesterone, remember that when progesterone gets stolen to help make cortisol when we are stressed, then this gets lower.  Also, there is so many environmental factors these days that attribute to Oestrogen dominance, in that, once they are ingested, they accommodate the same receptor sites that Oestrogen normally do, with a net result of high Oestrogens.

Once Oestrogen dominance has been established, then look at…

  1. Is stress a major contributor?
  2. Are environmental toxins a major contributor?
  3. Do you have a wonky COMT gene?

If you’d like to know more, you are welcome to join my free membership on facebook. Thyroid, Metabolic, Hormone Harmony Hub. 

I’d love to see you there

Inspiring Wellness

Beth 

No Motivation? It may be your FOXA2

No Motivation? It may be your FOXA2

Feel like this guy?

You know that feeling, you’ve got no energy, can’t be bothered, just want to sleep, know you should move, but you don’t.

Now you can say “Oh, it’s just my FOXA2″

What?? I’ve heard of that!

Unfortunately, being careful or not in choosing your food, there are loads of simple sugars in our diet and it is super easy to be eat a lot of simple sugars daily.  These can be obvious or disguised.

This regular steady influx of  sugars require consistently levels of insulin.  This is the  hormone is needed for the sugar to enter into our cells.  It is stored in our muscles first and if energy is not needed, that extra sugar goes into fat cells and makes more fat cells when these get full as well.  

FOXA2 is your get up and go enzyme, it makes you want to move around and exercise.  Interestingly, when you get appetite for your next meal and have to find the energy to prepare it, that is FOXA2 – creating the desire to eat and the energy to do it as our ancestors had to find the energy to hunt for their next meal.  

FOXA2 reduces with high insulin, which comes from consuming regular sugars, so the lethargy increases.

So to get your FOXA2 high, then you need to cut the sugars down so you have fasting states which reduces the insulin.

Simple really, so if you want to find the desire to move and exercise you are best to work on your diet first, then you will feel like uncurling and get moving.

If you’d like to know more about this or other topics, you are welcome to join my free membership on face book. Thyroid, Metabolic, Hormone Harmony Hub. 

I’d love to see you there

Inspiring Wellness

 

Beth  

 

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